Tuning and optimization for a variety of many-core architectures without changing a single line of implementation code using the Alpaka library

We present an analysis on optimizing performance of a single C++11 source code using the Alpaka hardware abstraction library. For this we use the general matrix multiplication (GEMM) algorithm in order to show that compilers can optimize Alpaka code effectively when tuning key parameters of the algorithm. We do not intend to rival existing, highly optimized DGEMM versions, but merely choose this example to prove that Alpaka allows for platform-specific tuning with a single source code. In addition we analyze the optimization potential available with vendor-specific compilers when confronted with the heavily templated abstractions of Alpaka. We specifically test the code for bleeding edge architectures such as Nvidia's Tesla P100, Intel's Knights Landing (KNL) and Haswell architecture as well as IBM's Power8 system. On some of these we are able to reach almost 50\% of the peak floating point operation performance using the aforementioned means. When adding compiler-specific #pragmas we are able to reach 5 TFLOPS/s on a P100 and over 1 TFLOPS/s on a KNL system.Comment: Accepted paper for the P\^{}3MA workshop at the ISC 2017 in Frankfur

Using System Dynamics Models to Understand and Improve Application Landscape Design

Application landscape design has become a key challenge for enterprises. For further exploration of related enterprise architecture benefits establishing shared mental models among all application landscape designers is required, i.e. architectural thinking. Thus, to complement existing approaches by modeling human behavior and decision effects which form implicit application landscape evolution principles, we propose the use of System Dynamics. We derive five guidelines from literature for developing a corresponding method. To exemplify the approach, a concrete causal loop diagram on the topic of technological standardization is presented. A subsequent evaluation based on expert interviews demonstrates the model content validity as well as the modeling method\u27s suitability to foster communication among different communities of practice

Towards a Process Model for Computer-Supported Collaborative Morphological Analysis

Morphological analysis (MA) is a method to analyze and design complex systems. MA fosters generation of a large number of solution/system design alternatives, yet it requires a considerable amount of manual effort. Therefore, a number of software tools have been developed to automate the construction of consistent design alternatives and support the exploration of the derived design space. However, available tools lack support for collaboration. This inhibits extended use of MA software in practice since system analysis and design tasks are typically conducted by teams. The purpose of this paper is to enhance the classical MA process model by collaboration support. We review seminal psychological research to guide our process design. We propose a collaborative process model that seeks to increase creativity and prevent psychological phenomena which might impair group performance. The revised process model serves as a basis for collaborative MA software implementations

On the Scalability of Data Reduction Techniques in Current and Upcoming HPC Systems from an Application Perspective

We implement and benchmark parallel I/O methods for the fully-manycore driven particle-in-cell code PIConGPU. Identifying throughput and overall I/O size as a major challenge for applications on today's and future HPC systems, we present a scaling law characterizing performance bottlenecks in state-of-the-art approaches for data reduction. Consequently, we propose, implement and verify multi-threaded data-transformations for the I/O library ADIOS as a feasible way to trade underutilized host-side compute potential on heterogeneous systems for reduced I/O latency.Comment: 15 pages, 5 figures, accepted for DRBSD-1 in conjunction with ISC'1

Puppet Regime vs. Lead Nation : Der lange Weg zur Anerkennung der DDR durch die USA

Am 4. September 1974 nahmen die Vereinigten Staaten von Amerika als 110. Staat der Welt und letzte der drei westlichen Siegermächte diplomatische Beziehungen zur Deutschen Demokratischen Republik auf. Mit der Unterzeichnung der Anerkennungsprotokolle zwischen der westlichen Leadnation und dem östlichen Gefolgsstaat ging die 25-jährige Ära der internationalen Ablehnung der ostdeutschen Staatlichkeit zu Ende. Bedingt durch die bundesdeutsch-amerikanische Erfolgsgeschichte, ist das Verhältnis zwischen dem „anderen“ Deutschland und den USA generell ein vernachlässigtes Kapitel in den deutsch-amerikanischen Beziehungen der Nachkriegszeit. Die vorliegende Arbeit will im Einzelnen untersuchen, inwiefern Ost-Berlins Initiativen in Richtung Washington, die durch die Détente veränderte Konstellation zwischen den Supermächten und die deutschdeutsche Entspannung Anteil an der diplomatischen Aufwertung der DDR hatten. Die Etablierung diplomatischer Beziehungen 1974 sollte der Höhepunkt des Verhältnisses DDR-USA bleiben. Zu einer grundlegenden Veränderung des politischen Gewichts der DDR in den USA kam es nicht, denn in Washington blieb die DDR stets „im Schatten" der Bundesrepublik

Course Allocation via Stable Matching

The allocation of students to courses is a wide-spread and repeated task in higher education, often accomplished by a simple first-come first-served (FCFS) procedure. FCFS is neither stable nor strategy-proof, however. The Nobel Prize in Economic Sciences was awarded to Al Roth and Lloyd Shapley for theirwork on the theory of stable allocations. This theory was influential in many areas, but found surprisingly little application in course allocation as of yet. In this paper, different approaches for course allocation with a focus on appropriate stablematchingmechanisms are surveyed. Two such mechanisms are discussed in more detail, the Gale- Shapley student optimal stable mechanism (SOSM) and the efficiency adjusted deferred acceptance mechanism (EADAM). EADAM can be seen as a fundamental recent contribution which recovers efficiency losses from SOSM at the expense of strategy-proofness. In addition to these two important mechanisms, a survey of recent extensions with respect to the assignment of schedules of courses rather than individual courses is provided. The survey of the theoretical literature is complemented with results of a field experiment, which help understand the benefits of stable matching mechanisms in course allocation applications

XTT assay of ex vivo saliva biofilms to test antimicrobial influences

Objective: Many dental diseases are attributable to biofilms. The screening of antimicrobial substances, in particular, requires a high sample throughput and a realistic model, the evaluation must be as quick and as simple as possible. For this purpose, a colorimetric assay of the tetrazolium salt XTT (sodium 3'-[1-[(phenylamino)-carbony]-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene-sulfonic acid hydrate) converted by saliva biofilms is recommended. Cleavage of XTT by dehydrogenase enzymes of metabolically active cells in biofilms yields a highly colored formazan product which is measured photometrically

XTT assay of ex vivo saliva biofilms to test antimicrobial influences

Objective: Many dental diseases are attributable to biofilms. The screening of antimicrobial substances, in particular, requires a high sample throughput and a realistic model, the evaluation must be as quick and as simple as possible. For this purpose, a colorimetric assay of the tetrazolium salt XTT (sodium 3'-[1-[(phenylamino)-carbony]-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene-sulfonic acid hydrate) converted by saliva biofilms is recommended. Cleavage of XTT by dehydrogenase enzymes of metabolically active cells in biofilms yields a highly colored formazan product which is measured photometrically

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.DFG, EXC 314, Unifying Concepts in Catalysi